HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate → 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 5237175 | — |
| Reactant | 3-(2-Chloro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine hydrochloride | HCID 68088462 | — |
| Product | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | 72% |
Reaction Steps
The synthesis of intermediate 1n is performed starting with 3-hydroxymethyl-1-BOC-pyrrolidine following the operating mode described for the synthesis of 1a (white solid, total yield 72%). TLC silica gel 60 F 254 Merck, CH2Cl2-MeOH—AcOH: 90:9:1, Rf=0.10
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946225B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-232bf9856edc4ab4a9fda85329a47854 |
| Source note | uspto-grants-2015_02 |