Benzene, 1-bromo-2-(trifluoromethyl)- → HCID 66957940, compound

HRID 1842354Notes

Reaction equation

HRID 1842354 reaction equation
[ClH:1].FC(F)(F)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.BrC1C=CC=CC=1[C:27]([F:30])([F:29])[F:28]>>[ClH:1].[Cl:1][C:4]1[CH:9]=[CH:8][C:7]([C:27]([F:30])([F:29])[F:28])=[CH:6][C:5]=1[NH:10][CH2:11][CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 66958083HCID 66958083, compound

Product 1

HCID 66957940HCID 66957940, compoundYield 47%

Procedure

The synthesis of intermediate 1s is conducted starting with 1-bromo-2-trifluoromethyl-benzene following the operating mode for the synthesis of 1r (white solid, total yield 47%). TLC silica gel 60 F 254 Merck, CH2Cl2-MeOH—NH4OH: 90:9:1, Rf=0.23.

Sources & evidence

ORD record
ord-6d4e48851886472b9d853c72afc8ec6f
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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