5-Fluoro-2-methylphenol → HCID 50917628, compound

HRID 1842361Notes

Reaction equation

HRID 1842361 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][NH:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:4][CH2:3]1.[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH3:28])=[C:25](O)[CH:26]=1>>[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH3:28])=[C:23]([CH:22]=1)[O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:19])[CH2:9][NH:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 27746165-Fluoro-2-methylphenolHCID 66957754HCID 66957754, compound

Product 1

HCID 50917628HCID 50917628, compoundYield 15%

Procedure

Compound 14 is prepared from intermediate 5b and from 5-fluoro-2-methyl-phenol following synthesis method 3 (yield: 15%).

Sources & evidence

ORD record
ord-94f3f1bfcd554028a4da3185a9b2e02f
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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