2-(Trifluoromethoxy)phenol → HCID 66957813, compound

HRID 1842364Notes

Reaction equation

HRID 1842364 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][O:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:4][CH2:3]1.[F:20][C:21]([F:31])([F:30])[O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1O>>[CH3:17][N:13]1[C:12](=[O:18])[C:11]([O:10][CH2:9][C:8](=[O:19])[N:5]2[CH2:4][CH2:3][CH:2]([O:1][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][C:21]([F:20])([F:31])[F:30])[CH2:7][CH2:6]2)=[CH:16][CH:15]=[N:14]1

Participants

3

Reactant 2

HCID 27772992-(Trifluoromethoxy)phenolHCID 66957928HCID 66957928, compound

Product 1

HCID 66957813HCID 66957813, compoundYield 20%

Procedure

Compound 21 is prepared from intermediate 5c and 2-trifluoromethoxy-phenol following synthesis method 3 (yield: 20%).

Sources & evidence

ORD record
ord-914e8800d70d4bbe88f53c854768a74b
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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