2-Chloro-4-fluorophenol → HCID 66957913, compound

HRID 1842365Notes

Reaction equation

HRID 1842365 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][O:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:4][CH2:3]1.[Cl:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1O>>[Cl:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:19])[CH2:9][O:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 748142-Chloro-4-fluorophenolHCID 66957928HCID 66957928, compound

Product 1

HCID 66957913HCID 66957913, compoundYield 18%

Procedure

Compound 22 is prepared from intermediate 5c and from 2-chloro-4-fluoro-phenol following synthesis method 3 (yield: 18%).

Sources & evidence

ORD record
ord-853c2f83fcc641ffb96dc60543f1c49e
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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