4'-Fluoro-2'-hydroxyacetophenone → HCID 66957968, compound

HRID 1842366Notes

Reaction equation

HRID 1842366 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][O:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:4][CH2:3]1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27](=[O:29])[CH3:28])=[C:23](O)[CH:22]=1>>[C:27]([C:24]1[CH:25]=[CH:26][C:21]([F:20])=[CH:22][C:23]=1[O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:19])[CH2:9][O:10][C:11]2[C:12](=[O:18])[N:13]([CH3:17])[N:14]=[CH:15][CH:16]=2)[CH2:6][CH2:7]1)(=[O:29])[CH3:28]

Participants

3

Reactant 2

HCID 27373264'-Fluoro-2'-hydroxyacetophenoneHCID 66957928HCID 66957928, compound

Product 1

HCID 66957968HCID 66957968, compoundYield 17%

Procedure

Compound 23 is prepared from intermediate 5c and from 1-(4-fluoro-2-hydroxy-phenyl)-ethanone following synthesis method 3 (yield: 17%).

Sources & evidence

ORD record
ord-48aab4e3f7dc4c74846696903aad1885
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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