1-Bromo-2-butyne → HCID 50916356, compound

HRID 1842369Notes

Reaction equation

HRID 1842369 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11](=[O:21])[CH2:12][NH:13][C:14]2[C:15](=[O:20])[NH:16][N:17]=[CH:18][CH:19]=2)[CH2:7][CH2:6]1.Br[CH2:31][C:32]#[C:33][CH3:34]>>[CH2:31]([N:16]1[C:15](=[O:20])[C:14]([NH:13][CH2:12][C:11]([N:8]2[CH2:9][CH2:10][CH:5]([O:4][C:3]3[CH:22]=[C:23]([C:26]([F:29])([F:27])[F:28])[CH:24]=[CH:25][C:2]=3[Cl:1])[CH2:6][CH2:7]2)=[O:21])=[CH:19][CH:18]=[N:17]1)[C:32]#[C:33][CH3:34]

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 50915333HCID 50915333, compound

Product 1

HCID 50916356HCID 50916356, compoundYield 9%

Procedure

Compound 46 is prepared from intermediate 7b and from 1-bromo-but-2-yne following synthesis method 6 (yield: 9%).

Sources & evidence

ORD record
ord-96a6d83cc5104a7a8b0aec359c435015
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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