HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2-Benzyl-4-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 3(2H)-Pyridazinone | HCID 68153 | — |
| Reactant | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | — |
| Reactant | (2-Benzyl-3-oxo-2,3-dihydro-pyridazin-4-ylamino)-acetic acid | HCID 66958017 | — |
| Product | 2-Benzyl-4-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one | HCID 50915676 | 30% |
Reaction Steps
Compound 48 is prepared from (2-benzyl-3-oxo-2,3-dihydro-pyridazin-4-ylamino)-acetic acid (obtained following the operating mode for 4e using benzyl bromide to alkylate nitrogen 2 of pyridazinone) and from intermediate 1a in base form, following synthesis method 2 (yield: 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946225B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-fd4a635ab60741fdbf8a0328b4df20a5 |
| Source note | uspto-grants-2015_02 |