HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 2-Isopropyl-4-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 3(2H)-Pyridazinone | HCID 68153 | — |
| Reactant | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | — |
| Reactant | (2-Isopropyl-3-oxo-2,3-dihydro-pyridazin-4-ylamino)-acetic acid | HCID 66957963 | — |
| Product | 2-Isopropyl-4-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one | HCID 50916003 | 69% |
Reaction Steps
Compound 49 is prepared from (2-isopropyl-3-oxo-2,3-dihydro-pyridazin-4-ylamino)-acetic acid (obtained following the operating mode for 4e using 2-iodo-propane to alkylate nitrogen 2 of pyridazinone) and from intermediate 1a in base form, following synthesis method 2 (yield: 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946225B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-66c8206aeb9e4e0aba2d7a65d3d445f0 |
| Source note | uspto-grants-2015_02 |