4-Amino-2-methyl-2,3-dihydropyridazin-3-one → 4-(2-Chloro-5-methyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

HRID 1842375Notes

Reaction equation

HRID 1842375 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[Cl:10][C:11]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:12]=1[O:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.Cl.FC(F)(F)C1C=CC=C[C:29]=1[O:30]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:29]([N:17]2[CH2:18][CH2:19][CH:14]([O:13][C:12]3[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:11]=3[Cl:10])[CH2:15][CH2:16]2)=[O:30])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 171951004-(2-Chloro-5-methylphenoxy)piperidine

Product 1

HCID 509160024-(2-Chloro-5-methyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amideYield 28%

Procedure

Compound 56 is prepared from intermediate 4c and from 4-(2-chloro-5-methyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a) applying synthesis method 7 (yield: 28%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 28%)

Sources & evidence

ORD record
ord-37cdb9b3c5d6407694b412032dab195f
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

Loading…