4-Amino-2-methyl-2,3-dihydropyridazin-3-one → 4-(2-Methyl-5-isopropyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

HRID 1842376Notes

Reaction equation

HRID 1842376 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[CH:10]([C:13]1[CH:14]=[CH:15][C:16]([CH3:26])=[C:17]([CH:25]=1)[O:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)([CH3:12])[CH3:11].Cl.FC(F)(F)C1C=CC=C[C:31]=1[O:32]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:31]([N:22]2[CH2:23][CH2:24][CH:19]([O:18][C:17]3[CH:25]=[C:13]([CH:10]([CH3:12])[CH3:11])[CH:14]=[CH:15][C:16]=3[CH3:26])[CH2:20][CH2:21]2)=[O:32])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 549096224-(5-Isopropyl-2-methyl-phenoxy)-piperidine

Product 1

HCID 509161794-(2-Methyl-5-isopropyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amideYield 51%

Procedure

Compound 57 is prepared from intermediate 4c and from 4-(5-isopropyl-2-methyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a,) applying synthesis method 7 (yield: 51%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 51%)

Sources & evidence

ORD record
ord-9f84386d1ca44e988162d60648a935e5
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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