4-(2-Methylphenoxy)piperidine → 4-(2-Methyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

HRID 1842378Notes

Reaction equation

HRID 1842378 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[C:10]1([CH3:23])[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl.FC(F)(F)C1C=CC=C[C:28]=1[O:29]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:28]([N:20]2[CH2:21][CH2:22][CH:17]([O:16][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[CH3:23])[CH2:18][CH2:19]2)=[O:29])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 36861704-(2-Methylphenoxy)piperidineHCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride

Product 1

HCID 509158364-(2-Methyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amideYield 50%

Procedure

Compound 59 is prepared from intermediate 4c and from 4-o-tolyloxy-piperidine (obtained following the method described for intermediate 1a), applying synthesis method 7 (yield: 50%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 50%)

Sources & evidence

ORD record
ord-a3c1de2574674ca099fa4fa8a1bb9585
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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