HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2-methyl-2,3-dihydropyridazin-3-one → 4-(4-Fluoro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2-methyl-2,3-dihydropyridazin-3-one | HCID 13103636 | — |
| Reactant | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | — |
| Reactant | HCID 66592088 | HCID 66592088 | — |
| Product | 4-(4-Fluoro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide | HCID 50915679 | 51% |
Reaction Steps
Compound 60 is prepared from intermediate 4c and from 4-(4-fluoro-3-trifluoromethyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a), applying synthesis method 7 (yield: 51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946225B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-9e36e2ecf4364167a7e4fa620b40212f |
| Source note | uspto-grants-2015_02 |