4-Amino-2-methyl-2,3-dihydropyridazin-3-one → HCID 50916174, compound

HRID 1842381Notes

Reaction equation

HRID 1842381 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH3:24])=[C:15]([CH:23]=1)[O:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl.FC(F)(F)C1C=CC=C[C:29]=1[O:30]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:29]([N:20]2[CH2:21][CH2:22][CH:17]([O:16][C:15]3[CH:23]=[C:11]([F:10])[CH:12]=[CH:13][C:14]=3[CH3:24])[CH2:18][CH2:19]2)=[O:30])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 66958087HCID 66958087, compound

Product 1

HCID 50916174HCID 50916174, compoundYield 46%

Procedure

Compound 68 is prepared from intermediate 4c and from 4-(5-fluoro-2-methyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a), applying synthesis method 7 (yield: 46%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 46%)

Sources & evidence

ORD record
ord-1f5c1824daca4de290ddc3cac9279fdc
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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