4-Amino-2-methyl-2,3-dihydropyridazin-3-one → HCID 50915842, compound

HRID 1842382Notes

Reaction equation

HRID 1842382 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[Cl:10][C:11]1[CH:23]=[C:22]([Cl:24])[C:21]([Cl:25])=[CH:20][C:12]=1[O:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.Cl.FC(F)(F)C1C=CC=C[C:30]=1[O:31]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:30]([N:17]2[CH2:18][CH2:19][CH:14]([O:13][C:12]3[CH:20]=[C:21]([Cl:25])[C:22]([Cl:24])=[CH:23][C:11]=3[Cl:10])[CH2:15][CH2:16]2)=[O:31])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 53409862HCID 53409862, compound

Product 1

HCID 50915842HCID 50915842, compoundYield 46%

Procedure

Compound 70 is prepared from intermediate 4c and from 4-(2,4,5-trichloro-phénoxy)-piperidine (obtained following the method described for intermediate 1a) applying synthesis method 7 (yield: 46%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 46%)

Sources & evidence

ORD record
ord-c16a3efc8f3341e5a0957ea18d1b42af
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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