Butyl bromide → HCID 58465799, compound

Participants

Reaction Steps

To a solution of ethyl 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate trifluoroacetate (2.6 g, 13.4 mmol) and 1-bromobutane (3.67 g, 26.8 mmol) in acetonitrile (26 mL) was added potassium carbonate (2.45 g, 17.7 mmol). The resulting mixture was refluxed overnight. The solvent was then evaporated to give a solid residue. Purification via flash chromatography (petroleum ether:EtOAc, 10:1) afforded ethyl 2-butyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate Intermediate 11 (0.7 g, 21%). 1H NMR (CDCl3, 300 MHz) δ7.11 (s, 1 H), 6.18 (s, 1 H), 4.25 (m, 2 H), 3.99 (m, 2 H), 3.53 (s, 2 H), 2.82 (t, J=5.6 Hz, 2 H), 2.46 (t, J=7.4 Hz, 2 H), 1.46 (m, 2 H), 1.30 (m, 2 H), 1.25 (t, J=7.1 Hz, 3 H), 0.87 (t, J=7.3 Hz, 2 H).

Provenance & Evidence