Triethylamine → HCID 58465801, compound

Participants

Reaction Steps

To a vial containing N-methylpyrrole-2-carboxylic acid (0.025 g, 0.2 mmol) was added HATU (0.076 g, 0.2 mmol), DCM (2 mL), and triethylamine (0.112 mL, 0.8 mmol). The solution was stirred at rt for 30 min then ethyl 2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepine-8-carboxylate 2,2,2-trifluoroacetate (0.0644 g, 0.2 mmol) in DMF (0.5 mL) was added. The mixture was stirred at rt for 2 h. The reaction was quenched by addition of DCM (1 mL), sat. NaHCO3 solution (0.5 mL), and water (1 mL). After separation, the aqueous layer was extracted with DCE (2×3 mL). The combined organic layers were concentrated to give crude ethyl 2-(1-methyl-1H-pyrrole-2-carbonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepine-8-carboxylate.

Provenance & Evidence