Hydrochloric Acid → HCID 58465742, compound

Participants

Reaction Steps

Ethyl 5-[(2-nitrophenyl)sulfonyl]-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylate (0.143 g, 0.362 mmol) was dissolved in a mixture of THF (4 mL) and methanol (1 mL) and to the solution was added 1.0 M of lithium hydroxide in water (1.5 mL, 1.5 mmol). The resulting mixture was stirred at room temperature for 2 hours. The mixture was concentrated, and the residue was dissolved in water (5 mL) and neutralized with 1.0 M hydrochloric acid in water (1.5 mL, 1.5 mmol). The resulting precipitate was collected via vacuum filtration to afford Intermediate 20 as a white solid (0.1166 g, 88%). LC-MS: (FA) ES+395.

Provenance & Evidence