Hydrochloric Acid → HCID 59539668, compound

Participants

Reaction Steps

To a solution of tert-butyl [(1R)-1-(5-fluoro-1-oxidopyridin-2-yl)ethyl]carbamate (1.47 g, 5.74 mmol) in dichloromethane (28.7 mL) was added 4 M hydrochloric acid in 1,4-dioxane (43.0 mL, 172 mmol). After 2 h, concentration gave the title compound as a hydrochloride salt (1.396 g). MS 157.1 (M+1). 1H NMR (500 MHz, CD3OD): δ 8.55 (dd, J=4.3, 2.4 Hz, 1 H); 7.70 (dd, J=9.0, 6.7 Hz, 1 H); 7.52 (ddd, J=9.1, 7.1, 2.4 Hz, 1 H); 4.80 (q, J=7.0 Hz, 1 H); 1.74 (d, J=7.0 Hz, 3 H).

Provenance & Evidence