Sodium Carbonate → HCID 66679841, compound

Participants

Reaction Steps

To a solution of ethyl 2,4-diiodo-1,3-oxazole-5-carboxylate (0.13 g, 0.32 mmol), (4-methylphenyl)boronic acid (48.0 mg, 0.35 mmol) and sodium carbonate (2.0 M; 0.40 mL, 0.80 mmol) in dioxane (2 mL) was added dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (13.1 mg, 16.0 μmol). The mixture was stirred at ambient temperature. After 18 h, sat. NaHCO3 was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts was dried over MgSO4, filtered and concentrated. Purification by silica gel chromatography (100% hexanes 50% hexanes/ethyl acetate) gave the title compound (40 mg). MS 357.0 (M+1).

Provenance & Evidence