HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzhydrylamine → 1-Chloro-3-[(diphenylmethyl)amino]propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzhydrylamine | HCID 7036 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Chloro-3-[(diphenylmethyl)amino]propan-2-ol | HCID 15024258 | 73% |
Reaction Steps
2-(Chloromethyl)oxirane (92 g, 1 mol) was added dropwise to a solution of diphenyl-methanamine (183 g, 1 mol) in CH3OH (1 L) at 0° C. then the mixture was stirred at r.t. overnight. The mixture was then concentrated in vacuo to give the title compound (201 g, 73%) which was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946235B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-978cc749e5aa4378afda70fff1e54a04 |
| Source note | uspto-grants-2015_02 |