3-(4-(Dibenzylamino)-2-fluorophenyl)oxetan-3-ol → 3-(4-Amino-2-fluorophenyl)oxetan-3-ol

Participants

Reaction Steps

To a stirred solution of 3-(4-(dibenzylamino)-2-fluorophenyl)oxetan-3-ol (2.15 g, 5.92 mmol, 1.0 eq) in THF (125 mL) was added 10% Pd/C (0.230 g) under argon and stirred under hydrogen balloon pressure for 16 h. The mixture was passed through celite, and the filtrate concentrated under vacuum. The resulting crude product was purified by CC using EtOAc/PE (7:3) to get 3-(4-amino-2-fluorophenyl)oxetan-3-ol (0.9 g, 73%; TLC system: EtOAc 100%, 0.5).

Provenance & Evidence