HCID 70816985, compound → HCID 86672154, compound

Participants

Reaction Steps

To a stirred THF (50 mL) solution of 2-(2-fluoro-4-nitrobenzyloxy)ethanol (5.0 g, 1.0 eq) 10% Pd/C was added and reaction mixture stirred under H2 gas balloon at for 16 h. The reaction mixture was passed through celite pad and the solvent evaporated. The residue was purified by CC using PE/EtOAc (3:2) as eluent to get 2-(4-amino-2-fluorobenzyloxy)ethanol (3.0 g, 60%, solid; TLC system: EtOAc/PE (3:2), Rf: 0.3).

Provenance & Evidence