Potassium Carbonate → HCID 70816329, compound

Participants

Reaction Steps

To a suspension of K2CO3 (8.8 g, 64.0 mmol, 1.5 eq) in methoxyethanol (100 mL) was added 1-(bromomethyl)-2-fluoro-4-nitrobenzene (10.0 g, 42.0 mmol, 1 eq) and the mixture was stirred at RT for 5 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (30 mL×2). The ethyl acetate layers were collected and dried (Na2SO4) and evaporated under vacuum. The residue was purified by CC using PE/EtOAc (17:3) as eluant to get 2-fluoro-1-((2-methoxyethoxy)methyl)-4-nitrobenzene (4 g, 40%) as oil (TLC system: PE/EtOAc (7:3), Rf: 0.5).

Provenance & Evidence