Acetone → HCID 86672155, compound

Participants

Reaction Steps

To a stirred solution of 3-fluoro-4-((2-methoxyethoxy)methyl)aniline (2.5 g, 13.0 mmol, 1 eq) in acetone (25 mL) was added pyridine (3.15 mL, 39.0 mmol, 3 eq) followed by phenyl chloroformate (1.64 mL, 13.0 mmol, 1 eq) at 0° C. and the mixture was stirred at RT for 1 h. The solvent was evaporated and resulting residue was purified by CC using ethyl acetate/PE (3:7) as eluent to get O-benzoyl-N-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)-hydroxylamine as white solid (TLC system: EtOAc/PE (1:1), Rf: 0.4).

Provenance & Evidence