1221119-68-1 → 2-(4-Amino-2-fluorophenyl)ethanol

HRID 1842955Notes

Reaction equation

HRID 1842955 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:11][CH2:12][OH:13])=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 1

HCID 866721581221119-68-1

Product 1

HCID 450906002-(4-Amino-2-fluorophenyl)ethanolYield 89.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirred solution of 2-(2-fluoro-4-nitrophenyl)ethanol (200 mg, 0.94 mmol, 1.0 eq) in ethanol (10 mL) was added 10% Pd/C (50 mg) and the mixture was stirred under a H2 gas balloon at RT for 5 h. The reaction mixture was passed through a celite bed and the solvent of the filtrate evaporated to get 2-(4-amino-2-fluorophenyl)ethanol (130 mg, 75%) as a viscous oil (TLC system: EtOAc/PE (1:1), Rf: 0.2).

Workup

  1. customthe solvent of the filtrate evaporated

Sources & evidence

ORD record
ord-9b2a5642517d49d6990effef8d5a1be0
Source dataset
uspto-grants-2015_02
Patent number
US08946204B2

Reaction notes

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