HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Fluoro-4-nitrophenyl)azetidin-3-ol → 1-(4-Amino-2-fluorophenyl)azetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Fluoro-4-nitrophenyl)azetidin-3-ol | HCID 53551678 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Amino-2-fluorophenyl)azetidin-3-ol | HCID 86672170 | 80.5% |
Reaction Steps
To a stirred solution of 1-(2-fluoro-4-nitrophenyl)azetidin-3-ol (160 mg, 0.75 mmol, 1.0 eq) in ethanol (10 mL) was added 10% Pd—C (20 mg) and stirred under H2 gas balloon at RT for 5 h. The reaction mixture was passed through celite and concentrated to obtain 1-(4-amino-2-fluorophenyl)azetidin-3-ol (110 mg, 80.0%, viscous oil) (TLC: EtOAc/PE (1:1), Rf: 0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946204B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-7a5e88cbf7c8406ba9e0a645a65908c7 |
| Source note | uspto-grants-2015_02 |