2-Fluoro-1-(2-(methylsulfonyl)ethyl)-4-nitrobenzene → 3-Fluoro-4-(2-(methylsulfonyl)ethyl)aniline

Participants

Reaction Steps

2-Fluoro-1-(2-(methylsulfonyl)ethyl)-4-nitrobenzene (700 mg, 2.83 mmol) was dissolved in ethyl acetate (7 mL), and to the solution was added (10%) Pd/C (70 mg) under argon atmosphere which was subjected to hydrogenation in a Parr apparatus and the reaction was continued to stir for 2 h. The reaction mixture was filtered through celite and was washed thoroughly with ethyl acetate and was concentrated under reduced pressure to obtain 3-fluoro-4-(2-(methylsulfonyl)ethyl)aniline (590 mg, 96%).

Provenance & Evidence