反应详情

To a solution of 2-(4-Amino-3-fluorophenyl)propionic acid (1 g, 5.459 mmol) in EtOH was added SOCl2 (0.6 ml, 8.189 mmol) at 0° C. The mixture was stirred for 2 hours at room temperature and then SOCl2 was removed under reduced pressure. The residue was diluted with EtOAc and washed with a saturated NaHCO3 solution. The resulting mixture was dried over MgSO4 and concentrated. The residue was purified by column chromatography to afford ethyl 2-(4-amino-3-fluorophenyl)propanoate (1 g, 87%).

1. customSOCl2 was removed under reduced pressure
2. additionThe residue was diluted with EtOAc
3. washwashed with a saturated NaHCO3 solution
4. dry with materialThe resulting mixture was dried over MgSO4
5. concentrationconcentrated
6. customThe residue was purified by column chromatography