Methyl 2-fluoro-4-nitrobenzoate → Methyl 4-amino-2-fluorobenzoate

Participants

Reaction Steps

To a stirred solution of methyl 2-fluoro-4-nitrobenzoate (1 g, 4.9 mmol, 1.0 eq) in EtOH (15 mL) was added 10% Pd/C (300 mg) and stirred under hydrogen gas balloon pressure. The reaction mixture was passed through celite, washed with EtOAC, the filtrate was concentrated to obtain methyl 4-amino-2-fluorobenzoate (800 mg; 95%) as a pale yellow solid (TLC: EtOAc/PE (2:3); Rf: 0.2).

Provenance & Evidence