HCID 43255694, compound → Surufatinib

HRID 1843053Notes

Reaction equation

HRID 1843053 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]([CH3:18])=[CH:12]3)[CH:5]=[CH:4][N:3]=1.[NH2:19][C:20]1[CH:21]=[C:22]([CH2:26][S:27]([NH:30][CH2:31][CH2:32][N:33]([CH3:35])[CH3:34])(=[O:29])=[O:28])[CH:23]=[CH:24][CH:25]=1>>[CH3:34][N:33]([CH3:35])[CH2:32][CH2:31][NH:30][S:27]([CH2:26][C:22]1[CH:23]=[CH:24][CH:25]=[C:20]([NH:19][C:2]2[N:7]=[C:6]([O:8][C:9]3[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=3)[NH:14][C:13]([CH3:18])=[CH:12]4)[CH:5]=[CH:4][N:3]=2)[CH:21]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 43255694HCID 43255694, compound2×HCID 598233595-((2-chloropyrimidin-4-yl)oxy)-2-methyl-1H-indole

Product 1

HCID 52920501Surufatinib

Procedure

The title compound of Formula A can be synthesized as the crude product of the compound of Formula A by the reaction of Compound 3 with 1-(3-aminophenyl)-N-(2-(dimethylamino)ethyl)methane-sulfonamide (Compound 4) in the presence of an acid, such as but not limited to acetic acid, formic acid, HCl, H2SO4, toluenesulfonic acid, trifluoroacetic acid, or ethanesulfonic acid acidic, and in a solvent, such as but not limited to, N,N-dimethylformamide (DMF), acetonitrile, tetrahydrofuran, ethanol, isopropanol, or toluene. The reaction can be carried out at a suitable temperature, such as a temperature ranging from 40 to 100° C.

Sources & evidence

ORD record
ord-da6700d7f07c44fd8e40ccdaab349420
Source dataset
uspto-grants-2015_02
Patent number
US08946249B2

Reaction notes

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