HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1843056Generated: November 2, 2026
Oxalyl chloride → 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride
https://huagongshe.com/reaction/1843056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid | HCID 86660076 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride | HCID 86660075 | — |
Reaction Steps
In 10 ml of dichloromethane, 467 mg of 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid are admixed with two drops of N,N-dimethylformamide and cooled to 0° C. Following the dropwise addition of 167 μl of oxalyl chloride, the reaction mixture is stirred at room temperature for three hours and then concentrated by evaporation. This gives the crude product 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946234B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-8dd05b45fa9347e3abbf331a6b713599 |
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| Source note | uspto-grants-2015_02 |
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