Potassium Fluoride → HCID 86660085, compound

Participants

Reaction Conditions

Reaction Steps

36.2 mg (0.19 mmol) of copper(I) iodide and 8.8 mg (0.15 mmol) of potassium fluoride are initially introduced in a heat-dried vial under argon, and 4 ml of N,N-dimethylformamide and 70.0 mg (0.12 mmol) of N-{4-chloro-3-[(2,2,2-trifluoroethyl)carbamoyl]phenyl}-3-(difluoromethoxy)-4-iodo-1-methyl-1H-pyrazole-5-carboxamide and 36.0 mg (254 μmol) of trifluoromethyltrimethylsilane are added. The reaction mixture is degassed in the ultrasound, flushed with argon and the closed vial is heated at 80° C. for two hours. The reaction solution is poured onto water and extracted with ethyl acetate. The organic phase is dried over sodium sulphate, filtered and concentrated by evaporation on a rotary evaporator. Chromatographic purification on silica gel gives 8.00 mg of N-{4-chloro-3-[(2,2,2-trifluoroethyl)carbamoyl]phenyl}-3-(difluoromethoxy)-1-methyl-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide (13%).

Provenance & Evidence