Hydrochloric Acid → 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid

Participants

Reaction Steps

1.15 g (3.59 mmol) of ethyl 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylate are dissolved in 4 ml of ethanol. 5.39 ml (10.8 mmol) of 2M sodium hydroxide solution are added and the reaction mixture is stirred for four hours at room temperature. 2M hydrochloric acid is added to establish a pH of 2-3. The resulting solid is filtered off with suction, washed with a small amount of water and triturated with cyclohexane. This gives 870 mg of 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid (83%) as a white solid.

Provenance & Evidence