Sodium Cyanide → HCID 58542582, compound

Participants

Reaction Steps

1.95 g (5.1 mmol) of 3-chloro-2-[5-fluor-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine and 0.30 g (6.1 mmol) of sodium cyanide are suspended in 20 ml of acetonitrile and the reaction mixture is then stirred under reflux for 16 hours. After cooling, the reaction mixture is poured onto a water/diethyl ether mixture. The aqueous phase is extracted three times with diethyl ether. The combined organic phases are washed twice with water and once with saturated sodium chloride solution and then dried over magnesium sulphate and filtered. The solvent is removed under reduced pressure on a rotary evaporator. The crude product is purified by means of flash chromatography on silica gel. This gives 1.7 g of 3-chloro-2-[5-cyano-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine (84%) as a yellow oil.

Provenance & Evidence