Methanol → HCID 178524928, compound

Participants

Reaction Steps

4.9 g (12.5 mmol) of 3-chloro-2-[5-cyano-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine are dissolved in 24 ml of methanol and admixed with 32.6 ml (494 mmol) of 50% strength sodium hydroxide solution (494 mmol). The reaction mixture is stirred for 7 days at room temperature. The reaction mixture is diluted with 10 ml of water and then concentrated to half the volume by evaporation. The mixture is then dripped onto concentrated hydrochloric acid with ice. The colourless solid which precipitates out is filtered off and dried in vacuo. This gives 2.95 g of 3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (79%) as a colourless solid.

Provenance & Evidence