Methanol → HCID 178499156, compound

Participants

Reaction Steps

0.8 g (2.6 mmol) of 3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-carboxylic acid are dissolved in 15.0 ml of methanol and then slowly admixed dropwise with 0.58 ml (7.9 mmol) of thionyl chloride. The reaction solution is then heated under reflux for 16 hours. After cooling, the solvent is removed under reduced pressure on a rotary evaporator and the residue is taken up in ethyl acetate. The organic phase is carefully admixed with saturated sodium hydrogencarbonate solution. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulphate and filtered. The solvent is removed under reduced pressure on a rotary evaporator. This gives 0.75 g of methyl 3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxylate (96%) as a colourless oil.

Provenance & Evidence