Methyl iodide → HCID 86660093, compound

HRID 1843072Notes

Reaction equation

HRID 1843072 reaction equation
[CH2:1]([N:3]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([C:11]([F:14])([F:13])[F:12])[C:5]([C:15]([F:21])([F:20])C(F)(F)F)=[N:4]1)C.[F:22]C(F)(F)C1C(C(F)(F)F)=C(C(OCC)=O)NN=1.IC>>[CH3:1][N:3]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([C:11]([F:12])([F:13])[F:14])[C:5]([C:15]([F:20])([F:21])[F:22])=[N:4]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 585425391-Ethyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxylic acidHCID 178470424HCID 178470424, compound

Product 1

HCID 86660093HCID 86660093, compound

Procedure

1-Methyl-3,4-bis(trifluoromethyl)-1H-pyrazole-5-carboxylic acid is synthesized analogously to the preparation of 1-ethyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid from ethyl 3,4-bis(trifluoromethyl)-1H-pyrazole-5-carboxylate and iodomethane.

Sources & evidence

ORD record
ord-37e34df2dba84ad5a8798a4b7b6e3135
Source dataset
uspto-grants-2015_02
Patent number
US08946234B2

Reaction notes

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