Bromine → HCID 87377841, compound

Participants

Reaction Steps

At 40° C., 3.27 g (20.5 mmol) of bromine are added dropwise to a solution of 4.65 g (18.6 mmol) of 1-methyl-3-heptafluoropropyl-1H-pyrazole in 18 ml of water and the reaction mixture is afterstirred firstly for one hour at 60° C. and then for 18 hours at room temperature. The aqueous phase is extracted three times with dichloromethane and the organic phase is dried over sodium sulphate. The dichloromethane is distilled off at reduced pressure on a rotary evaporator. This gives 5.75 g of 1-methyl-3-heptafluoropropyl-4-bromo-1H-pyrazole (78%) as an oil.

Provenance & Evidence