Sulfuric Acid → HCID 58542527, compound

Participants

Reaction Conditions

Reaction Steps

4.70 g (15.4 mmol) of 2-methyl-6-(pentafluoroethyl)-5-(trifluoromethyl)pyrimidine-4-carbonitrile are dissolved in 80 ml of concentrated sulphuric acid. The reaction mixture is stirred for 12 hours at 100° C. and then added to 300 ml of ice water. The aqueous phase is extracted four times with ethyl acetate. The combined organic phases are dried over sodium sulphate and the solvent is concentrated by evaporation under reduced pressure on a rotary evaporator. Half of the crude product was purified by, means of flash chromatography on silica gel (eluent: cyclohexane/ethyl acetate=1/1). This gives 0.63 g of 2-methyl-6-(pentafluoroethyl)-5-(trifluoromethyl)pyrimidine-4-carboxamide (13%) as a viscous oil.

Provenance & Evidence