Hydrochloric Acid → HCID 58542554, compound

Participants

Reaction Steps

200 mg (0.97 mmol) of methyl 3-(difluoromethoxy)-1-methyl-1H-pyrazole-5-carboxylate are dissolved in 6.5 ml of methanol and 1.94 ml of 1M sodium hydroxide solution is added. The reaction mixture is stirred overnight at room temperature, then admixed with 1M hydrochloric acid and extracted with ethyl acetate. The organic phase is dried over sodium sulphate, filtered and concentrated by evaporation in vacuo. This gives 180 mg of 3-difluoromethoxy-1-methyl-1H-pyrazole-5-carboxylic acid (97%).

Provenance & Evidence