Chlorosuccinimide → HCID 58542508, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 400 mg (1.94 mmol) of methyl-3-(difluoromethoxy)-1-methyl-1H-pyrazole-5-carboxylate in 10 ml of N,N-dimethylformamide is admixed at 0° C. with 389 mg (2.91 mmol) of N-chlorosuccinimide and then stirred for 8 hours at 80° C. The reaction solution is poured onto water and extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulphate and concentrated by evaporation in vacuo. This gives 466 mg of methyl 4-chloro-3-(difluoromethoxy)-1-methyl-1H-pyrazole-5-carboxylate (99%).

Provenance & Evidence