反应详情

A solution of 1.50 g (5.95 mmol) of ethyl 3-(hydroxymethyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazole-5-carboxylate in 100 ml of dichloromethane is admixed with 4.14 g (47.6 mmol) of manganese(IV) oxide and heated under reflux for four hours. The cooled reaction mixture is filtered over Celite and concentrated by evaporation on a rotary evaporator. This gives 1.36 g of ethyl 3-formyl-1-methyl-4-(trifluoromethyl)-1H-pyrazole-5-carboxylate (91%).

1. temperatureheated
2. temperatureunder reflux for four hours
3. customThe cooled reaction mixture
4. filtrationis filtered over Celite
5. concentrationconcentrated by evaporation on a rotary evaporator