Water → HCID 58542576, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 700 mg (2.48 mmol) of ethyl 3-(2-fluoropropan-2-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrazole-5-carboxylate in 10 ml of methanol is admixed with 208 mg (3.72 mmol) of potassium hydroxide and 1 ml of water and heated at 50° C. for one hour. The reaction mixture is concentrated by evaporation, admixed with water and extracted with diethyl ether. The aqueous phase is acidified with dilute hydrochloric acid and extracted twice with ethyl acetate, and the organic phase is dried over sodium sulphate and, after filtration, is concentrated by evaporation. This gives 498 mg of 3-(2-fluoropropan-2-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (79%).

Provenance & Evidence