Triethylamine → HCID 58542500, compound

Participants

Reaction Steps

557 mg (3.10 mmol) of 2,2,3,3,3-pentafluoropropanethioamide and 746 mg (3.41 mmol) of ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate (commercially available or can be prepared in accordance with Journal of Fluorine Chemistry 2004, 125, 1287-1290) are dissolved in 15 ml of acetonitrile, and 0.86 ml (6.19 mmol) of triethylamine is added dropwise. The reaction mixture is heated at reflux for 5 hours and then left at room temperature for two days. Chromatographic purification on silica gel gives 568 mg of ethyl 2-(pentafluoroethyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate (13%).

Provenance & Evidence