Hydrochloric Acid → HCID 58542567, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 540 mg (1.57 mmol) of ethyl 2-(pentafluoroethyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate in 3 ml of methanol and 1 ml of water is admixed with 94.4 mg (2.36 mmol) of sodium hydroxide solution and heated at 60° C. for two hours. The reaction mixture is acidified with conc. hydrochloric acid and extracted four times with dichloromethane, and the organic phase is washed with saturated sodium chloride solution, dried over magnesium sulphate and, after filtration, is concentrated by evaporation. This gives 417 mg (min. 50% strength, max. 82%) of 2-(pentafluoroethyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid.

Provenance & Evidence