Bromine → HCID 87377841, compound

Participants

Reaction Steps

At 40° C., 3.27 g (20.45 mmol) of bromine are added dropwise to a solution of 4.65 g (18.59 mmol) of 1-methyl-3-heptafluoropropyl-1H-pyrazole in 18 ml of water and the reaction mixture is afterstirred firstly at 60° C. for 1 hour and then at room temperature for 18 hours. The aqueous phase is extracted three times with dichloromethane and the organic phase is dried over sodium sulphate. The dichloromethane is distilled off at reduced pressure on a rotary evaporator. This gives 5.75 g (77.85% of theory) of 1-methyl-3-heptafluoropropyl-4-bromo-1H-pyrazole as an oil.

Provenance & Evidence