HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)pyridine → 1-Amino-4-trifluoromethylpyridinium 2,4,6-trimethylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)pyridine | HCID 138055 | — |
| Reactant | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Amino-4-trifluoromethylpyridinium 2,4,6-trimethylbenzenesulfonate | HCID 86671366 | — |
Reaction Steps
To a solution of 4-trifluoromethylpyridine (2.23 g, 15.2 mmol) in CH2Cl2 (66 mL) at 0° C., O-(mesitylsulfonyl)hydroxylamine (3.27 g, 15.2 mmol) was added. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was filtered to afford the desired product with quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946257B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-19cbd1eae1d948a99e78af11fe066759 |
| Source note | uspto-grants-2015_02 |