Triethyl orthoacetate → HCID 68312936, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in example 2 section d (56.4 mg, 0.169 mmol) in EtOH (1.5 mL), PTSA monohydrate (3.21 mg, 0.017 mmol) and triethyl orthoacetate (547 mg, 3.37 mmol) were added. The reaction mixture was heated in a CEM Explorer microwave oven at 145° C. and 270 W for 2.5 hours. The crude residue was cromategraphed on a silica gel flash system (ISCO Rf) using CH2Cl2/MeOH mixtures of increasing polarity, a eluent to afford the desired product (15% yield).

Provenance & Evidence