4-Benzyl-2-(fluoromethyl)-1-methylpiperazine → 2-(Fluoromethyl)-1-methylpiperazine

HRID 1843185Notes

Reaction equation

HRID 1843185 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH:10]([CH2:15][F:16])[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:16][CH2:15][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[CH3:14]

Participants

4

Reactant 1

HCID 197772584-Benzyl-2-(fluoromethyl)-1-methylpiperazine

Product 1

HCID 197772702-(Fluoromethyl)-1-methylpiperazineYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 111c (3 g, 13.5 mmol) and MeOH (80 mL), and the resulting mixture was added Pd/C (10%) (300 mg). The reaction mixture was stirred under hydrogen gas (H2) for 15 h. After the reaction was finished, it was filtered and concentrated to afford 111d as a yellow oil (1.6 g, yield 90%).

Workup

  1. customA 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer
  2. filtrationit was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-18d7a667b8da4f3a83feccc74aeca03a
Source dataset
uspto-grants-2015_02
Patent number
US08946213B2

Reaction notes

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